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36 If patients are already close to their glycaemic target before starting GLP-1RAs, the dose of their other antihyperglycaemic medications, especially insulin and sulfonylureas, may need to be decreased at GLP-1RA prescription, to prevent hypoglycaemia

Factors such as: Degree of insulin resistance Presence of other conditions (cardiovascular disease, fatty liver disease, sleep apnoea) Family history of diabetes or obesity Age and menopausal status Previous weight loss attempts and patterns of weight regain Safety considerations and tolerability play an important role

One question that comes up often is: Does Wegovy lead to heartburn or cause acid reflux symptoms? Understanding this, along with other common side effects, is essential for guiding patients safely and keeping them comfortable throughout their weight-loss journey

In human studies, 3g of glycine (equivalent to about 15g of collagen peptides) taken 1 hour before bedtime reduced daytime sleepiness, shortened sleep onset latency, and improved subjective sleep quality

Treatment begins at 2.5 mg weekly with gradual dose titration every 4 weeks to minimise side effects and assess digestive tolerance